C-Fos Digital Expression Analysis in Human PapillomavirusRelated Oral Squamous Cell Carcinoma

Background: Fos Proto-Oncogene (c-Fos) represents a well analyzed gene involved in solid malignancies’ development and progression. The corresponding protein forms heterodimer with c-jun, strong transcription factor. C-Fos/c-Jun complex influences critically the intracellular signal transduction to nucleus. Our aim was detect evaluate c-Fos expression patterns oral squamous cell carcinomas (OSCC) tissues. Materials Methods: Fifty (n=50) formalin-fixed, paraffin-embedded primary OSCCs tissue sections were used. Immunohistochemistry digital image analysis implemented for identifying evaluating levels, respectively. Results: C-Fos over (moderate high imunostaining intensity values) observed 28/50 (56%) cores, whereas low rates detected rest of examined cases (22/50- 44%). overall strongly associated stage grade tumors (p=0.014, p=0.003, respectively) also Human papillomavirus (HPV) persistent infection (p=0.004). up regulation is frequently OSCCs. Conclusion: levels are correlated an aggressive phenotype (advanced stage/lymph node metastasis) patients OSCC, especially HPV positive cases, High Risk subtypes. Due its elevated oncogenic activity, should be target novel therapeutic strategies OSCC combined or not other oncogenes involving signaling pathways.